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InhibitorSelect™ 96-Well Protein Kinase Inhibitor Library I (Cat. No. 539744)
InhibitorSelect™ 96-Well Protein Kinase Inhibitor Library II (Cat. No. 539745)
NEW! InhibitorSelect™ 384-Well Protein Kinase Inhibitor Library I (Cat. No. 539743)
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- InhibitorSelect™ Libraries contain 80 or 160 well-characterized, potent, and structurally diverse kinase inhibitors in DMSO solution in a 96- or 384-well plate.
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| The InhibitorSelect™ Protein Kinase Library I contains multiple inhibitors against mainly three major kinase classes, Tyrosine kinases (TK), AGC kinases (containing PKA, PKG, and PKC families), and Atypical kinases. |
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Akt | Aurora | Bcr-Abl | DAG | DNA-PK | EGFR | FLT3 | cFMS | IGFR | IRAK | JAK | Lck | c-Met | p70 S6 | PDGFR | PDK1 | PI 3-K | PKC | PKR | Rho | Src | Syk | TGF-b R | VEGFR | | | | |
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| The InhibitorSelect™ Protein Kinase Library II contains multiple inhibitors against mainly two major kinase classes, CMGC kinases ( CDK/ MAPK/ GSK/ CDK-Like kinases) and CaMK ( Ca 2+ /calmodulin-dependent protein Kinase) |
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ATM | ATR | Aurora | CaMK | Cdks | Chk1,2 | CK1,2 | GSK-3 | ERK | MEK | MAPK | MNK1 | JNK | IKK | SK | | | |
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| The InhibitorSelect™ 384-Well Protein Kinase Inhibitor Library I contains 160 kinase inhibitors in one 384-well plate. |
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Akt | ATM | ATR | Aurora | Bcr-Abl | CaMK | Cdks | cFMS | Chk1,2 | CK1,2 | c-Met | DAG | DNA-PK | EGFR | ERK | FLT3 | GSK-3 | IGFR | IKK | IRAK | JAK | JNK | LcK | MAPK | MEK | MNK1 | p70S6 | PDGFR | PDK1 | PI3-K | PKC | PKR | Rho | SK | Src | Syk | TGF-bR | VEGFR | | | | |
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| Convenient for... |
| Target identification in drug discovery | | | • | Screen for small molecule inhibitors that block receptor mediated signal transduction | | Biochemical pathway analysis | | | • | Screen small molecule inhibitors that may affect either upstream or downstream targets | | Screening of new protein kinases | | | • | Profile against inhibitors with known biological activity and structure | | Other pharmaceutical applications | | | • | Useful for cell phenotypic screening | | Cell-based assays |
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Highest Quality Control - Purity by HPLC (≥95%)*
- Lot specific data for every inhibitor in solution is provided.
- DMSO-resistant polypropylene deep-well microplates
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Format
- Convenient 96-well or 384-well, polypropylene, deep-well microplates
- 10 mM DMSO solution
- 50 ml/ well (96-well) or 25 ml/well (384-well)
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| Inhibitor Characteristics | | - Cell-permeable*
- Potent and Selective*
- ATP-competitive*
- Reversible*
- Structurally diverse
- Some Target Multiple kinases
- Known pharmacological activity
- Stable in DMSO, and supplied with lot-specific HPLC data
- Less toxic
| | Comprehensive Documentation | - Structure Data Files (SDF)
- Published IC50/Ki values
- CAS Numbers
- Literature Citations
- PubChem Compound ID (where available)
- Inhibitor Description
- Molecular weight
- Molecular structure
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 Free download of a comprehensive data set for all of our InhibitorSelect Libraries, including a list of all inhibitors and structure files. |
| For more detailed information on our InhibitorSelect Protein Kinase Libraries, including the SD files and list of individual inhibitors, please help us by answering these brief questions. Once you complete this information you will be able to download the files: (fields marked with a * are required) |
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