Resins and reagents for the PEGylation of peptides
PEG-NovaTagTM resins
PEG-NovaTagTM resins:
allow direct synthesis of peptides with C-terminal PEG spacer lead to improved solubility of peptides and biotinylated peptides by introduction of PEG spacer compatible with standard Fmoc peptide synthesis protocols
Novabiochem's PEG-based building blocks for solid phase peptide synthesis can be introduced using standard coupling methods, such as PyBOP or TBTU and are compatible with standard TFA cleavage protocols. Applications in peptide and protein chemistry are numerous: as flexible spacers to link peptides to separate peptides from reporter groups such as fluorophores and biotin to increase peptide solubility both in aqueous and organic solvents to delay enzymatic digestion in biological systems