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PEGylation
Peptide Synthesis
Automated Peptide Synthesis
Solid Phase Organic Synthesis
Solution Phase Organic Synthesis
Bioconjugation
Peptide Ligation
Peptide Labeling
Biomolecule labeling


Resins and reagents for the PEGylation of peptides 
  
PEG-NovaTagTM resins

PEG-NovaTagTM resins:

allow direct synthesis of peptides with
   C-terminal PEG spacer
lead to improved solubility of peptides and
   biotinylated peptides by introduction of
   PEG spacer
compatible with standard Fmoc peptide
   synthesis protocols

R1 = spacer
R2 or R3 = label or protecting group
04-12-3911Universal PEG NovaTagTM resin
04-12-3908Biotin-PEG NovaTagTM resin
  
  
Bifunctional amino-PEG-acid spacers

Novabiochem's PEG-based building blocks for solid phase peptide synthesis can be introduced using standard coupling methods, such as PyBOP or TBTU and are compatible with standard TFA cleavage protocols.
Applications in peptide and protein chemistry are numerous:
as flexible spacers to link peptides
to separate peptides from reporter groups such as fluorophores and biotin
to increase peptide solubility both in aqueous and organic solvents
to delay enzymatic digestion in biological systems

Boc-protected
01-63-0205Boc-NH-PEG-COOH.DCHA (9 atoms)
 
01-63-0206Boc-NH-(PEG)3-COOH (16 atoms)
 
01-63-0207Boc-NH-(PEG)5-COOH (22 atoms)
 
01-63-0151Boc-NH-(PEG)27-COOH (88 atoms)
 
Fmoc-protected
01-63-0203Fmoc-NH-(PEG)-COOH (9 atoms)
 
01-63-0198Fmoc-NH-(PEG)2-COOH (13 atoms)
 
01-63-0141Fmoc-NH-(PEG)2-COOH (20 atoms)
 
01-63-0199Fmoc-NH-(PEG)3-COOH (16 atoms)
 
01-63-0200Fmoc-NH-(PEG)4-COOH (19 atoms)
 
01-63-0204Fmoc-NH-(PEG)5-COOH (22 atoms)
 
01-63-0150Fmoc-NH-(PEG)27-COOH (88 atoms)
 
Others
01-63-0103O-(Azidoethyl)-O'-(N-diglycolyl-2-aminoethyl)-heptaethyleneglycol
 
01-63-0102O-(N-Boc-2-aminoethyl)-O'-(N-diglycolyl-2-aminoethyl)-hexaethyleneglycol
 
01-63-0109O-(N-Fmoc-2-aminoethyl)-O'-(2-carboxyethyl)-undecaethyleneglycol
 
Protected PEG diamine
01-63-0143Trt-NH-(PEG)2-NH2
 
Solubilizing biotinylation reagents
01-63-0133Biotinyl-NH-(PEG)2-COOH · DIPEA (20 atoms)
 
04-12-1279Fmoc-Asp(biotinyl-PEG)-OH
 
04-12-1250Fmoc-Glu(biotinyl-PEG)-OH
 
   
 
 View PDF of Letters 01/07: Derivatives for enhancing peptide synthesis.

For a comprehensive survey on NovaTagTM resins see:
Letters 1/04

For a summary of Novabiochem PEG reagents see:
Letters 3/06

Letters 1/07