Benzyloxycarbonylleucyl-norleucinal White to off-white solid. PACKAGED UNDER INERT GAS. A cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of b-amyloid precursor protein to b-amyloid (Ab). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells. Purity: ≥94% by HPLC. CAS 117591-20-5. Z-Leu-Nle-CHO Ref.: Lee, M.S., et al. 2000. Nature 405, 360. Yamazaki, T., et al. 1997. Biochemistry 27, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Shiba, E., et al. 1996. Anticancer Res. 16, 773. Pinter, M., et al. 1994. Neurosci. Lett. 170, 91. Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231. Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
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