Biologics 34.1 features a lead article on the role of TGF-b signaling in tumor suppression and oncogenesis. This pathway is also attracting significant attention in stem cell biology. Featured in this issue are our collection of inhibitors of TGF-beta receptor Kinase and antibodies to various Smads. Also included are several new inhibitors of NF-kB activation pathway, various protein kinases and lipid kinases.