Anti-b-Site Amyloid Precursor Protein (APP)-Cleaving Enzyme
Anti-b-Secretase

Host: Rabbit

Isotype: IgG

Immunogen: a synthetic peptide [(C)IRLPLRSGLGGAPLGLRLPR] corresponding to amino acids 26-45 of human BACE

Form: Liquid

Formulation: Undiluted serum.

Preservative: None

Comments: Recognizes the ~65 kDa and ~75 kDa glycosylated forms of BACE in CHO cells transfected with BACE cDNA corresponding to BACE with an intact prodomain.

Ref.: Pinnix, I., et al. 2001. FASEB J. 15, 1810. Bennett, B.D., et al. 2000. J. Biol. Chem. 275, 37712. Capell, A., et al. 2000. J. Biol. Chem. 275, 30849. Lin X., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 1456. Vassar, R., et al. 1999. Science 286, 735. Yan, R., et al. 1999. Nature 402, 533.