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  Calpain Inhibitor III
Cat. No. 208722  
All Categories » Calbiochem » Inhibitors » Protease » Calpain

Carbobenzoxy-valinyl-phenylalaninal
MDL 28170

White lyophilized solid. A potent, cell-permeable inhibitor of calpain I and II (Ki = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity. Purity: ≥95% by HPLC. CAS 88191-84-8.

Z-Val-Phe-CHO

Ref.: Chatterjee, S., et al. 1998. J. Med. Chem. 41, 2663. Rami, A., et al. 1997. Neurosci. Res. 27, 93. Yamazaki, T., et al. 1997. Biochemistry 36, 8377. Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655. Chard, P.S., et al. 1995. Neuroscience 65, 1099. Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

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Merck Chemicals EUR list price is displayed (pricing with local distributors may vary). NOTE: In Stock status is based on item availability worldwide.

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25 mgY€158

SolubilityMolecular FormulaMol. Wt.
DMSO C22H26N2O4 382.5 


Related Products:
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208721: ALLM
208722: Calpain Inhibitor III
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208722: Calpain Inhibitor III - English
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Related Categories:
All Categories » Calbiochem » Inhibitors » Protease » Calpain

Selected Citations:
  1. Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
  2. So-Young Park and Adriana Ferreira. (2005) The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which Tau mediates β-amyloid-induced neurodegeneration. Journal of Neuroscience 25, 5365-5375.
  3. Jonathan Rios-Doria, et al. (2004) Cleavage of b-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
  4. Jonathan Rios-Doria, et al. (2004) Cleavage of ß-catenin by calpain in prostate and mammary tumor cells. Cancer Research 64, 7237-7240.
 
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