5-Ethyl-4-(4′-methoxyphenyl)-thiazolyl-2-amine Tan solid. PROTECT FROM LIGHT. A cell-permeable thiazolyl compound that binds to CBFb (core binding factor b) and allosterically disrupts CBFa/Runx1 binding to CBFb both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~ 100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells. Purity: ≥97% by HPLC. Ref.: Gorczynski, M.J., et al. 2007. Chem. Biol. 14, 1186.
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