rChTx
Pyr-FTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS

Lyophilized solid. Salt-free. HYGROSCOPIC. Recombinant charybdotoxin expressed in E. coli. High-affinity ligand that is a potent blocker of the tetraethylammonium (TEA) and voltage-sensitive Ca²⁺-activated K⁺ channel. Biological activity: inhibition of Kv1.3 K⁺ channels expressed in Xenopus oocytes (IC₅₀ = 1 nM). Purity: ≥98% by HPLC.

H-Pyr-Phe-Thr-Asn-Val-Ser-Cys⁷-Thr-Thr-Ser-Lys-Glu-Cys¹³-Trp-Ser-Val-Cys¹⁷-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys²⁸-Met-Asn-Lys-Lys-Cys³³-Arg-Cys³⁵-Tyr-Ser-OH (disulfide 7 → 28; 13 → 33; 17 → 35)

Ref.: Russell, S.N., et al. 1994. Am. J. Physiol. 267, C1729. Asano, M., et al. 1993. Br. J. Pharmacol. 108, 214. Price, M., et al. 1989. Proc. Natl. Acad. Sci. USA 86, 19171. Gimenez-Gallego, G., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 3329.
R: 20/21/22; S: 36