rrCNTF Lyophilized. HYGROSCOPIC. Recombinant, rat ciliary neurotrophic factor expressed in E. coli. Neuronal survival factor that promotes the survival and differentiation of a variety of neuronal cell lines. Prevents lesion-induced death of motor neurons in adults. Reported to increase K+ currents in SK-N-SH neuroblastoma cells. Biological activity: induces choline acetyltransferase (EC50 = 50 ng/ml). Purity: ≥98% by SDS-PAGE. Merck Index: 14, 2274 Ref.: Lesser, S.S., and Lo, D.C. 1995. J. Neurosci. 15, 253. Sendtner, M., et al. 1994. J. Neurobiol. 25, 1436. Sendtner, M., et al. 1990. Nature 345, 440. |