AG 1517
4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline
Compound 32
SU 5271 White solid. PROTECT FROM LIGHT. An extremely potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. Purity: ≥97% by HPLC. Ref.: Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267. Fry, D.W., et al. 1994. Science 265, 1093.
Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266. |
