Z-D(OMe)E(Ome)VD(OMe)-FMK White to slightly brown solid. PROTECT FROM MOISTURE. A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. Purity: ≥90% by TLC. Z-Asp(OCH3)-Glu(OCH3)-Val-Asp(OCH3)-FMK Ref.: Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312. Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641. Nicholson, D.W. 1996. Nature Biotech. 14, 297. Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841. Nicholson, D.W., et al. 1995. Nature 376, 37.
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