DPP IV Inhibitor IV
(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile Light brown solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV activity and augment GLP-1 and insulin response after glucose intake and significantly reduce plasma glucose concentration. Purity: ≥97% by HPLC. Please note: 328.4 is the anhydrous molecular weight; please refer to the vial label for the lot-specific hydration and molecular weight. CAS 440100-64-1. Ref.: Takasaki, K., et al. 2004. Eur. J. Pharmacol. 505, 237. Takasaki, K., et al. 2004. Eur. J. Pharmacol. 486, 335. Takasaki, K., et al. 2004. J. Pharmacol. Sci. 95, 291.
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