3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide
Sore to Dynamin Pale yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Purity: ≥98% by HPLC. CAS 304448-55-3. Ref.: Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607. Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955. Macia. E., et al. 2006. Dev. Cell 10, 839.
R: 50; S: 22-24/25 |
