Myristyltrimethylammonium Bromide
Tetradecyltrimethylammonium Bromide
TTAB White solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable cationic surfactant that reversibly inhibits dynamin GTPase activity (IC50 = 3.15 µM) by targeting the PH domain and interfering with phospholipid binding. Shown to block dynamin I-dependent SVE (synaptic vesicle endocytosis) in rat brain synaptosomes and dynamin II-dependent RME (receptor-mediated endocytosis) in non-neuronal HeLa, A431, and COS-7 cells. Inhibition is competitive with respect to PS and noncompetitive with respect to GTP. Purity: ≥99% by Titration. CAS 1119-97-7. Merck Index: 14, 6336
Ref.: Quan, A., et al. 2007. Mol. Pharmacol. 72, 1425. Hill, T.A., et al. 2004. Bioorg. Med. Chem. Lett. 14, 3275.
R: 34; S: 26-36/37/39-45 |
