Receptor tyrosine-protein kinase erbB-2
Tyrosine kinase-type cell surface receptor HER2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2

Liquid. In 100 mM NaCl, 50 mM Tris-HCl, 15 mM reduced glutathione, 5 mM DTT, 20% glycerol, pH 8.0. AVOID FREEZE/THAW CYCLES. Recombinant, human ErbB2 fused at the N-terminus to a GST-thrombin cleavage site sequence and expressed in S. frugiperda insect cells using a baculovirus expression system. ErbB2 is a component of a neuregulin-receptor complex that regulates neuromuscular synapse formation. It plays an important role in muscle spindle development. Overexpression of ErbB2 is reported in approximately 30% of all breast cancer cases. Specific activity: ≥20 U/mg protein. One unit is defined as the amount of enzyme that will transfer 1 nmol phosphate to Poly(Glu,Tyr)_4:1 per min at 30°C using variable concentrations of ATP (100 nM to 5.8 µM).

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