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Inhibitor Libraries

Protease and Phosphatase Inhibitor Cocktails

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  EST
Cat. No. 330005  
All Categories » Calbiochem » Inhibitors » Protease » Other

E-64d
(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane Ethyl Ester
Loxistatin

White solid. A cell-permeable, irreversible inhibitor of cysteine proteases. Similar to E-64 (Cat. No. 324890) but devoid of charged groups. Reported to inhibit calpain-1 activation. The inhibitory activity of EST has been attributed to E-64c, the free acid formed by hydrolysis of the ester in vivo. Used in animal models of muscular dystrophy. Purity: ≥98% by TLC. RTECS RR0404300, CAS 88321-09-9.

Ref.: Inomata, M., et al. 1996. Arch. Biochem. Biophys. 328, 129. Mehdi, S. 1991. Trends Biochem. Sci. 16, 150. McGowan, E.B., et al. 1989. Biochem. Biophys. Res. Commun. 158, 432. Tamai, M., et al. 1987. J. Pharmacobiodyn. 10, 678. Komatsu, K., et al. 1986. Exp. Neurol. 91, 23. Tamai, M., et al. 1986. J. Pharmacobiodyn. 9, 672.
R: 36/37/38; S: 26-36

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Merck Chemicals USD list price is displayed (pricing with local distributors may vary). NOTE: In Stock status is based on item availability worldwide.

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1 mgY$111.00

SolubilityMolecular FormulaMol. Wt.
CHCl3 or EtOH C17H30N2O5 342.4 


Related Literature:

Calcium Metabolism and Related Products Brochure
Inhibitor Sourcebook
Protease and Phosphatase Inhibitor Cocktails Brochure

Material Safety Data Sheets:
330005: EST - English
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Related Categories:
All Categories » Calbiochem » Inhibitors » Protease » Other

Selected Citations:
  1. Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
 
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