Edelfosine
1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine White solid. A cell-permeable cytotoxic agent that shows selective cytocidal activity against neoplastic cells and virally transformed cells. Selectively inhibits phosphatidylinositol-specific phospholipase C (PI-PLC; IC50 = 15 µM) but does not inhibit phosphatidylcholine-specific PLC or PLD. Promotes apoptosis in mitogen-activated, but not resting, T lymphocytes in a dose- and time-dependent manner. Also promotes rapid and selective apoptosis in human leukemic cells. Purity: ≥95% by TLC. RTECS YK0718000, CAS 70641-51-9. Ref.: Harguindey, J., et al. 2000. Apoptosis 5, 87. Cabaner, C., et al. 1999. Br. J. Pharmacol. 127, 813. Powis, G., and Phil, D. 1994. Cancer Metastasis Rev. 13, 91. Helfman, D., et al. 1993. Cancer Res. 53, 2955. Mollinedo, F., et al. 1993. Biochem. Biophys. Res. Commun. 192, 603. Powis, G., et al. 1992. Cancer Res. 52, 2835. Oishi, K., et al. 1988. Biochem. Biophys. Res. Commun. 157, 1000.
R: 40; S: 22-36 |
