H-Asn-Asn-Trp-Asn-Asn-OH Lyophilized. Supplied as a trifluoroacetate salt. HYGROSCOPIC. A pentapeptide that acts as an essential extracellular death factor (EDF) for the toxin-antitoxin module mazEF-mediated cell death in E. coli cultures. The killing activity of EDF is shown to be mazEF-dependent at low concentrations, but becomes more and more mazEF-independent at concentrations higher than 200 ng/ml. Sequence analysis of E. coli genome reveals the gene products of zwf (coding glucose-6-phosphate dehydrogenase) and ygeO as likely precursors of EDF. Purity: ≥97% by HPLC. H2N-Asn-Asn-Trp-Asn-Asn-CO2H Ref.: Kolodkin-Gal, I., et al. 2007. Science 318, 652.
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