NSC 75503
4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo. Purity: ≥95% by HPLC. Ref.: Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455. |
