rmIL-12 Lyophilized. Carrier-free. Recombinant, mouse interleukin-12 expressed in S. frugiperda insect cells. Pleiotropic cytokine that is produced by monocytes/macrophages, B cells, and connective tissue type mast cells. Also known as natural killer cell stimulatory factor and cytotoxic lymphocyte maturation factor. Biological activity: ED50 = 0.01-0.05 ng/ml as determined by the dose-dependent secretion of IFN-g from PHA- and IL-2-activated mouse splenocytes that have been co-stimulated with PMA.. Purity: ≥95% by SDS-PAGE. Contaminants: Endotoxin: ≤100 pg/µg IL-12. RTECS NM9745000. Ref.: Gillessen, S., et al. 1995. Eur. J. Immunol. 25, 200. Zou, J.J., et al. 1995. J. Biol. Chem. 270, 5864. Brunda, M.J., et al. 1994. J. Leukoc. Biol. 55, 280. Smith, T.J., et al. 1994. Eur. J. Immunol. 24, 822. Wolf, S.F., et al. 1994. Stem Cells 12, 154. Schoenhaut, D.S., et al. 1992. J. Immunol. 148, 3433. |
