rhIL-15 Lyophilized. Lyophilized from a sterile solution in PBS containing 50 µg BSA/µg cytokine. Recombinant, mouse interleukin-15 expressed in E. coli. Stimulates the proliferation of T and B lymphocytes and NK cells. Expressed by a wide variety of cells including peripheral blood mononuclear cells, fibroblasts, and epithelial cells. Unlike IL-2, IL-15 is not detected in activated T cells. Essential for maintaining memory-T cells over long periods of time. Induces STAT6 activation and IL-4 production in bone marrow-derived mast cells. Biological activity: ED50 = 0.5-2.0 ng per ml as measured in a cell proliferation assay using IL-15-responsive human megakaryocytic leukemic cell line, MO7e.. Purity: ≥97% by SDS-PAGE. Contaminants: Endotoxin: ≤100 pg/µg IL-15. Ref.: Becker, T.C., et al. 2002. J. Exp. Med. 195, 1541. Giri, J., et al. 1994. EMBO J. 13, 2822. Grabstein, K., et al. 1994. Science 264, 965. |
