5-Hydroxy-1,4-naphthlenedione
5-Hydroxy-p-naphthoquinone Orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A highly selective cell-permeable, irreversible inhibitor of PPlases (peptidyl-prolyl cis/trans isomerases of the parvulin family). Other known PPlase inhibitors such as cyclosporin A, FK506, and rapamycin are not reported to inhibit the parvulin family of PPlases. The inactivation is shown to occur via the addition of thiol groups to juglone and not by any redox process. Exhibits bacteriostatic and fungistatic effects. Reported to be cytotoxic towards eukaryotic cells and to block transcription by RNA polymerase II. Purity: ≥95% by HPLC. RTECS QJ5775000, CAS 481-39-0. Merck Index: 14, 5269
Ref.: Chao, S.H., et al. 2001. Nucleic Acids Res. 29, 767. Hennig, L., et al. 1998. Biochemistry 37, 5953.
R: 36/37/38-25; S: 45-26 |
