Kamycin White to off-white solid. Contains more than 98% kanamycin A. An aminoglycoside antibiotic effective against Gram-positive and Gram-negative organisms. Inhibitor of protein biosynthesis that acts on the 30S ribosome, causing misreading of the genetic code. May cause renal damage and ototoxicity. RTECS NZ3225030, CAS 25389-94-0. Merck Index: 14, 5281
Ref.: Lech, K., and Brent, R. 1995. in Current Protocols in Mol. Biol. Vol. 1 (Ausubel, F.M., et al., eds.) John Wiley & Sons, New York. Kahn, R.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 9295. Cardon, G.H., et al. 1993. Plant J. 3, 773. Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition. Cold Spring Harbor, New York. p.1.6, A.6. Korzybyski, T., et al. 1978. In Antibiotics, Origin, Nature, and Properties 1, 690. Stiffler, P.W., et al. 1974. Antimicrob. Agents Chemother. 6, 516. Umezawa, S., et al. 1968. J. Antibiot. 21, 367.
R: 61; S: 26-45 |
