3-(2-(1H-Benzo[d]imidazol-1-yl)-6-(2-morpholinoethoxy)pyrimidin-4-ylamino)-4-methylphenol Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a highly potent Lck (lymphocyte specific kinase) inhibitor (IC50 = 3 nM; [ATP] = 10 µM). Shown to block IL-2 release in Jurkat E6-1 T cell line (IC50 = 54 nM) stimulated by CD3 cross-linking and PMA. Purity: ≥97% by HPLC. Ref.: Sabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 5973.
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