LMB Liquid. Supplied at 20 µg/ml (5 µg in 250 µl) in absolute ethanol PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An antifungal antibiotic that acts as an inhibitor of nuclear export because of its ability to interact with and impair the function of the nuclear export factor CRM1. It is about twice as potent as Leptomycin A (Cat. No. 431051) in inhibiting nucleocytoplasmic translocation of Rev, blocks the Rev-dependent export of mRNA into cytoplasm, and suppresses HIV-1 replication in primary human monocytes (IC50 = 600 pM). In addition, LMB effectively induces the accumulation of p53 in the nucleus of normal fibroblasts as well as protects p53 from Mdm2-mediated ubiquitination and degradation. Purity: ≥95% by HPLC. Caution! Product contains volatile liquid. Keep product cold at all times. CAS 87081-35-4. Ref.: Kau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78. Menendez, S., et al. 2003. Br. J. Cancer 88, 636. Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66. Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112. Lain, S., et al. 1999. Exp. Cell Res. 248, 457. Wolff, B., et al. 1997. Chem. Biol. 4, 139. Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150. Komiyama, K., et al. 1985. J. Antibiot. 38, 427. |
