4-Hydroxy-2-methyl-N-(5-methyl-2-thiazoyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of COX-2 (IC50 = 4.7 µM) relative to COX-1 (IC50 = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro. Purity: ≥98% by HPLC. CAS 71125-38-7. Merck Index: 14, 5826 Ref.: Blanco, F.J., et al. 1999. J. Rheumatol. 26, 1366. Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115. Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195. |