Mitocin C
MMC Blue-violet solid. Provided as 2 mg antibiotic and 48 mg NaCl. PROTECT FROM LIGHT. Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G2 phase. Purity: ≥95% by HPLC. RTECS CN0700000, CAS 50-07-7. Merck Index: 14, 6215
Ref.: Kruyt, F.A., et al. 1996. Blood 89, 938. Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394. Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24. Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899. Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752. McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471. Tomasz, M., et al. 1987. Science 235, 1204.
R: 28; S: 36/37-45-28 |
