EVNLYAAEF Liquid. A 1 mM (250µg in 280 µl) solution in DMSO. Supplied as a trifluoroacetate salt. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. PACKAGED UNDER INERT GAS. An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (Ki = 48 nM). This aspartyl protease inhibitor is designed from the template of the b-secretase site of Swedish b-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala. Purity: ≥90% by HPLC. CAS 314266-76-7. Glu-Val-Asn-Leu-Y-Ala-Ala-Glu-Phe [Y denotes replacement of CONH by (S)-CH(OH)CH2] Ref.: Ghosh, A.K., et al. 2001. J. Med. Chem. 44, 2865. Turner III, R.T., et al. 2001. Biochemistry 40, 10001. Ghosh, A.K., et al. 2000. J. Am. Chem. Soc. 122, 3522. Hong, L., et al. 2000. Science 290,150. |
