4-(3-(4-Chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)pyrimidine
SC-409 Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1d and p38a (IC50 = 20 and 40 nM, respectively). Shown to affect p38b, PKA, JNK2, and JNK3 activity (IC50 = 2.3, 10.5, 19.7, and 69.7 µM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38d/g, even at a conentraion of 10 µM or higher. An excellent tool for studying p38-mediated responses both in cells in vitro and in animals in vivo. Purity: ≥98% by HPLC. CAS 271576-77-3. Ref.: Mbalaviele, G., et al. 2006. J. Pharm. Exp. Ther. 317, 1044. Liu, Y.H., et al. 2005. J. Card. Fail. 11, 74. Yu, J.J., et al. 2003. J. Immunol. 171, 6112. |
