N-(2-Methoxy-4-thiomethyl)benzoyl-4-benzylpiperidine Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable piperidinamide compound that acts as a reversible and highly potent inhibitor of MAPK p38a (IC50 = 32 nM) with no detectable activity against p38g even at concentrations as high as 10 µM. Shown to effectively block the differentiation of L8 myoblasts to myotubes at 10 µM in a reversible manner. Not a competitive inhibitor with respect to either ATP or substrate. Purity: ≥98% by HPLC. CAS 349087-34-9. Ref.: Friedmann, Y., et al. 2006. Mol. Pharmacol. 70, 1395. R: 36/37/38; S: 22-24/25-36/37/39 |