3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 (Cat. Nos. 208712 and 208713) and 370 nM for calpain-2 (Cat. Nos. 208715 and 208718)] directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and cathepsin L. Does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis in thymocytes. Purity: ≥95% by HPLC. Ref.: Lin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539. Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960. Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150. Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687. |
