2-(5-Bromo-1H-indol-3-yl)-N-hydroxyacetamide
PDF1B Inhibitor
PDF2 Inhibitor Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable hydroxamate compound that acts as an active site-binding, potent, and selective inhibitor against bacterial type peptide deformylases PDF2 and PDF1B (IC50 = 13 and 35 nM, respectively), while exhibiting little activity against human (mPDF) and A. thaliana (PDF1A) mitochondrial PDFs (IC50 = 360 and 130 µM, respectively). Shown to display similar antibiotic potency against E. coli and B. subtilis as, but less toxic towards human cells than, Actinonin. Purity: ≥95% by HPLC. Ref.: Boularot, A., et al. 2007. J. Med. Chem. 50, 10. |
