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| | Anti-P-Glycoprotein Mouse mAb (C219) |
|  | Cat. No. 517310 |
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| Host: Mouse | | Isotype: IgG2a | | Immunogen: SDS-solubilized plasma membranes of a multidrug resistant (MDR) Chinese hamster ovary (CHO) cell line and a multidrug resistant human cell line | | Form: Liquid | | Formulation: In PBS, 1% BSA. | | Preservative: ≤0.1% sodium azide | | Positive Control: Cell lines or frozen tissue, such as liver or colon | | Comments: Recognizes the ~170 kDa MDR1 and MDR3 isoforms of P-glycoprotein. | | Ref.: Beck, W.T., et al. 1996. Cancer Res. 56, 3010. Toth, K., et al. 1992. Am. J. Pathol. 140, 1009. Schinkel, A.H., et al. 1991. Cancer Res. 51, 2628. Chan, H.S.L., et al. 1988. Lab Invest. 59, 870. | | Immunoblotting Lee, G., et al. 2001. J. Pharmacol. Exp. Ther. 299, 204. |
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Merck Chemicals list price is displayed (pricing with local distributors may vary). NOTE: In Stock status is based on item availability worldwide.
| C219 | hamster, human, mouse, rat | FC, FS, IB, IC, IP, PS
See Key |
| - Zhigang Zhang, Jin-Ying Wu, William Hait and Jin-Ming Yang. (2004) Regulation of the stability of P-glycoprotein by ubiquitination.. Molecular Pharmacology 66, 395-403.
- Severine Ledoux, et al. (2003) Glucose depletion enhances P-glycoprotein expression in hepatoma cells: role of endoplasmic reticulum stress response. Cancer Research 63, 7284-7290.
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