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  Phosphodiesterase 4A4, Human, Recombinant, S. frugiperda
Cat. No. 524731  
All Categories » Calbiochem » Proteins and Enzymes » Phosphodiesterases

cAMP-specific phosphodiesterase 4A isoform 4
PDE4A4

Liquid. In 150 mM NaCl, 10 mM Tris-HCl, pH 8.3. AVOID FREEZE/THAW CYCLES. Full-length, recombinant, human phosphodiesterase 4A4 expressed in S. frugiperda insect cells using a baculovirus expression system. Supplied as a partially purified, catalytically active preparation. Activity: ≥0.5 units/µl. One unit is defined as the amount of enzyme that will convert 1 pmole cAMP to AMP per min at 30°C, pH 7.5.

Ref.: Gibson, L.C.D., et al. 2006. Eur. J. Pharmacol. 538, 39. Xu, R.X., et al. 2000. Science 288, 1822.

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Phosphodiesterase 4A4 was treated with increasing concentrations of the inhibitor Rolipram (Cat. No. 557330) and activity determined. The IC50 is 1.3 µM.

Related Literature:

Biologics 32.2

Material Safety Data Sheets:
524731: Phosphodiesterase 4A4, Human, Recombinant, S. frugiperda - English
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All Categories » Calbiochem » Proteins and Enzymes » Phosphodiesterases