3-(4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenol White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110a, p110b, p110d, p110g, PI3-KC2b, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. Purity: ≥97% by HPLC. CAS 371935-74-9. Ref.: Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840. Fan, Q.W., et al. 2006. Cancer Cell 9, 341. Knight, Z.A., et al. 2006. Cell 125, 733. |
