3′-(a-Amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyladenosine, 2HCl White to off-white solid. PROTECT FROM MOISTURE. Protein synthesis inhibitor. Inhibits translation by causing premature release of nascent polypeptide chains. Induces DNA fragmentation in thymocytes and in human HL-60 leukemia cells. Purity: ≥98% by TLC. RTECS AU7355000, CAS 58-58-2. Merck Index: 14, 7943 Ref.: Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149. Constam, D.B., et al. 1995. J. Biol. Chem. 270, 26931. Wirth, M., et al. 1994. J. Virol. 68, 566. Claeyssens, S., et al. 1993. FEBS Lett. 315, 7. Hechler, U., et al. 1993. Biochem. Biophys. Res. Commun. 194, 1305. Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976. de la Luna, S. and Ortín, J. 1992. Methods Enzymol. 216, 376. Kalpaxis, D.L. and Drainas, D. 1992. Arch. Biochem. Biophys. 300, 629. Shipston, M.J. and Antoni, F.A. 1992. Biochem. Biophys. Res. Commun. 189, 1382. |