L 779450
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM & Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38a, GSK-3b, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf. Purity: ≥97% by HPLC. CAS 303727-31-3. Ref.: Takle, A.K., et al. 2006. Bioorg. Med. Chem. Lett. 16, 378. Shelton, J.G., et al. 2003. Leukemia 17, 1765.
R: 36/37/38; S: 26-36-45 |
