4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole Off-white solid. PROTECT FROM LIGHT. A highly specific and cell-permeable inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). Purity: ≥98% by HPLC. CAS 152121-47-6. Ref.: Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503. Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49. LoGrasso, P.V., et al. 1997. Biochem. 36, 10422. Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028. Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723. Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586. Cuenda, A., et al. 1995. FEBS Lett. 364, 229. Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171. Lee, J.C., et al. 1994. Nature 372, 739.
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